Skill UI

Provides expert guidance on designing, implementing, and optimizing cutting-edge computer vision pipelines. Expertise spans real-time object detection (YOLO26), advanced promptable segmentation (SAM 3), and leveraging Vision Language Models (VLMs) for complex visual reasoning. Ideal for building high-performance systems in robotics, autonomous vehicles, and industrial inspection, including 3D reconstruction and edge deployment optimization.

DiffDock is a cutting-edge deep learning tool leveraging diffusion models to predict the 3D binding poses of small molecule ligands to protein targets. It supports structure-based drug discovery, enabling single-complex docking, batch virtual screening, and lead optimization. Users can input protein structures (PDB) or sequences, along with diverse ligand formats (SMILES, SDF, MOL2). The tool outputs predicted poses and confidence scores, making it crucial for identifying potential drug candidates, though it does not predict binding affinity.

The ESM skill provides comprehensive tools for computational biology, leveraging ESM3 and ESM-C models. It enables sophisticated protein sequence generation, structure prediction (sequence to 3D structure), inverse folding (structure to sequence design), and generating function-conditioned proteins. Use it for de novo protein design, feature embedding, and advanced structural analysis in bioinformatics workflows.