Skill UI

Provide a comprehensive toolkit for RNA velocity inference in single-cell RNA-seq data, modeling unspliced/spliced kinetics to infer differentiation directions, latent time, and driver genes while complementing Scanpy pipelines.

This skill provides a comprehensive framework for vulnerability prioritization by combining three crucial data points: CISA's Known Exploited Vulnerabilities (KEV) catalog (confirming real-world exploitation evidence), EPSS scores (predicting exploitation probability), and CVSS metrics (assessing intrinsic severity). It builds a multi-factor prioritization engine to determine the most critical CVEs for immediate remediation, assisting security teams in managing large vulnerability backlogs efficiently.

Conducts comprehensive, sector-specific threat landscape assessments by profiling key threat actors, mapping attack vectors, and detailing associated MITRE ATT&CK TTPs (covering financial, healthcare, energy, etc.). Utilizing sophisticated data analysis via Python stacks and integrating real-time threat intelligence feeds (ISAC, CVEs), this tool generates highly actionable intelligence for risk management, security investment prioritization, and high-level board-level reporting on industry exposure.

Anndata is a Python package for handling annotated data matrices, storing experimental measurements alongside observation and variable metadata. It supports single-cell genomics analysis, managing h5ad and Zarr files efficiently. Users can read, write, concatenate, and subset data with sparse matrix support. It integrates with the scverse ecosystem including Scanpy and scvi-tools. Ideal for biological data workflows requiring efficient storage and manipulation.

scVelo is a Python package for RNA velocity analysis in single-cell RNA-seq data. It estimates cell state transitions from unspliced/spliced mRNA dynamics, infers trajectory directions, computes latent time, and identifies driver genes to reveal cell fate decisions.