Skill UI

A practical decision framework for determining whether to use regular expressions or Large Language Models (LLMs) when parsing structured text (e.g., forms, quizzes, invoices). It recommends starting with deterministic, low-cost regex for 95-98% of structured data, and only invoking expensive LLM calls for identifying and validating ambiguous edge cases, optimizing both cost and accuracy.

Provides programmatic access to the CZ CELLxGENE Census (61M+ cells) for querying standardized single-cell expression, metadata, embeddings, and stats across tissues and diseases, supporting scanpy and ML workflows.

Programmatic access to the COSMIC cancer mutation database for downloading mutations, Cancer Gene Census, mutational signatures, fusions, copy number, expression, and resistance data to fuel oncology research or bioinformatics pipelines after authentication.

Connect to NCBI's GEO repository, search series/samples/platforms via Entrez queries, fetch profiles, and download raw/processed matrices using GEOparse for transcriptomics and expression analysis workflows.

PyDESeq2 brings the DESeq2 differential expression workflow to Python, letting users load bulk RNA-seq counts, specify design formulas, fit DESeq2 models, run Wald tests with FDR correction, optionally apply apeGLM shrinkage, and export gene-level statistics within pandas/AnnData pipelines.

Query the Reactome Content and Analysis Services (or the reactome2py client) to fetch pathway hierarchies, map genes, run overrepresentation/expression analyses, and explore disease interactions for systems biology research.

Probabilistic deep-learning framework built on PyTorch for single-cell omics; handles batch correction, integration, multimodal and spatial data, differential expression, and transfer learning with unified APIs.

Access multi-dimensional cancer genomics data via cBioPortal REST API for mutation, copy-number, expression, and survival insights across TCGA/GENIE studies, enabling target validation and clinical association analyses programmatically with Python clients.

Query the GTEx portal and API to retrieve tissue-specific gene expression, eQTL, sQTL, and variant-level regulatory data for interpreting GWAS loci and exploring gene regulation across 54 human tissues.

This skill provides programmatic access to the CZ CELLxGENE Census, a comprehensive collection of versioned public single-cell and spatial transcriptomics data. It enables efficient querying of population-scale cell metadata, gene expression slices, and embeddings without downloading entire datasets. Suitable for analyzing human, mouse, and other organism data across tissues and diseases. Integrates with Scanpy, AnnData, and TileDB-SOMA for large-scale analysis and machine learning workflows.

Unified CLI and Python interface to 20+ bioinformatics databases for gene info, BLAST/BLAT, viral sequences, AlphaFold structures, enrichment, disease and expression queries.

High-performance Python DataFrame library built on Apache Arrow. Covers expression-based API, lazy query optimization, streaming out-of-core processing, aggregations, window functions, joins, and pandas migration for ETL and analytics pipelines.