Skill UI

A comprehensive workflow for systematically reviewing medical evidence. It allows users to search databases for clinical studies, build curated citation collections, grade evidence using established frameworks like GRADE, and generate professionally formatted, structured reports in academic citation styles (e.g., AMA). Ideal for conducting literature reviews and supporting clinical research. This tool helps transform raw medical data into actionable, structured knowledge.

Provide REST API access to ClinPGx, the successor to PharmGKB, for querying gene-drug interactions, CPIC/DPWG/FDA guidelines, allele functions, and evidence that supports precision dosing and pharmacogenomics-driven clinical decisions.

Query NCBI ClinVar for variant clinical significance, mixing gene/condition searches, API/FTP downloads, and VCF annotations to support genomic medicine interpretation workflows.

Programmatic access to the COSMIC cancer mutation database for downloading mutations, Cancer Gene Census, mutational signatures, fusions, copy number, expression, and resistance data to fuel oncology research or bioinformatics pipelines after authentication.

Query Ensembl’s RESTful API to access gene annotations, sequences, variants, orthologs, and assembly mappings across 250+ species, enabling integration into genomic research pipelines.

Access NCBI Gene data via E-utilities or Datasets API to look up genes by symbol or ID, retrieve RefSeqs, GO terms, chromosomal locations, phenotypes, and run batch workflows for annotation pipelines.

Query the NHGRI-EBI GWAS Catalog for SNP-trait associations, fetch study metadata, variant and trait details, and download summary statistics via the web or REST APIs to support genetic epidemiology and polygenic risk modeling.

Direct Python helpers for KEGG's REST API, covering database metadata, listing, search, retrieval, ID conversion, linkage, and drug interactions to power pathway and gene analysis.

Query the Reactome Content and Analysis Services (or the reactome2py client) to fetch pathway hierarchies, map genes, run overrepresentation/expression analyses, and explore disease interactions for systems biology research.

Query gnomAD via GraphQL to retrieve allele frequencies, constraint scores, and loss-of-function annotations for population-informed variant interpretation and rare disease gene prioritization.

Query the GTEx portal and API to retrieve tissue-specific gene expression, eQTL, sQTL, and variant-level regulatory data for interpreting GWAS loci and exploring gene regulation across 54 human tissues.

Query the Monarch Initiative API to explore disease-gene-phenotype associations across species, enabling rare disease gene discovery, phenotype-to-gene mapping, and cross-species modeling via integrated HPO and model organism data.