Skill UI

PyDESeq2 brings the DESeq2 differential expression workflow to Python, letting users load bulk RNA-seq counts, specify design formulas, fit DESeq2 models, run Wald tests with FDR correction, optionally apply apeGLM shrinkage, and export gene-level statistics within pandas/AnnData pipelines.

Structured workflow for building hierarchical Bayesian models with PyMC 5+, covering data prep, NUTS sampling, diagnostics, posterior checks, and predictive inference.

Guides developers through scikit-learn workflows for classical supervised and unsupervised tasks, data preprocessing, evaluation schemes, hyperparameter tuning, and end-to-end pipelines when building interpretable production models.

Toolkit for Python-based survival and time-to-event modeling with scikit-survival, supporting Cox models, ensemble learners, SVMs, and evaluation metrics for censored data.

SimPy is a powerful, process-based discrete-event simulation framework written in Python. It is designed for modeling complex systems where entities interact with shared resources and time-based events occur, such as manufacturing lines, service queues, network traffic, or logistics networks. Use this skill to analyze resource contention, simulate process optimization, conduct capacity planning, and model dynamic system behaviors.

Statsmodels is a comprehensive Python library dedicated to advanced statistical modeling and econometrics. It provides tools for rigorous statistical inference, including Ordinary Least Squares (OLS), Generalized Linear Models (GLM), mixed-effects models, and time series analysis (ARIMA). Use this skill for detailed diagnostics, coefficient estimation, hypothesis testing, and producing publication-ready statistical reports in fields like econometrics and biostatistics.

This skill provides zero-shot time series forecasting using Google's TimesFM foundation model. It forecasts any univariate time series (like sales, sensor data, or weather) without requiring custom model training. The model delivers point forecasts along with calibrated prediction intervals (quantiles), offering a robust and probabilistic view of future trends. It is ideal for rapid, reliable forecasting across diverse time-based datasets.

TorchDrug is a PyTorch-native toolbox for building graph neural networks tailored to molecules, proteins, and biomedical knowledge graphs, covering property prediction, generation, retrosynthesis, and knowledge graph reasoning with curated datasets and models.

Query the Monarch Initiative API to explore disease-gene-phenotype associations across species, enabling rare disease gene discovery, phenotype-to-gene mapping, and cross-species modeling via integrated HPO and model organism data.

Provide a comprehensive toolkit for RNA velocity inference in single-cell RNA-seq data, modeling unspliced/spliced kinetics to infer differentiation directions, latent time, and driver genes while complementing Scanpy pipelines.

PyMC is a powerful Python library for probabilistic programming and advanced Bayesian inference. This comprehensive guide details the full workflow for building, fitting, and validating complex Bayesian models. Learn to implement hierarchical structures, perform MCMC sampling (NUTS), conduct posterior predictive checks (PPC), and effectively quantify uncertainty using industry best practices.

Placeholder skill entry for risk modeling workflows that outlines basic analytics and scenario planning used to quantify potential losses and guide mitigation decisions.