Skill UI

Access the BRENDA SOAP API to retrieve enzyme kinetic parameters, reaction equations, organism-specific data, and environmental preferences, enabling biochemical research, metabolic pathway reconstruction, and enzyme engineering workflows.

RDKit delivers a Python-based cheminformatics toolkit for parsing SMILES/SDF, computing descriptors, generating 2D/3D coordinates, fingerprinting, searching substructures, managing reactions, and visualizing molecules, ideal for drug discovery and computational chemistry workflows.

Query the Reactome Content and Analysis Services (or the reactome2py client) to fetch pathway hierarchies, map genes, run overrepresentation/expression analyses, and explore disease interactions for systems biology research.

Python cheminformatics toolkit for fine-grained molecular control: SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D coordinate generation, similarity, reactions, and visualization.

This comprehensive guide details the process of implementing a secure and robust system for handling Palantir Foundry webhook events. It covers key steps including API-based webhook registration, mandatory signature verification with replay protection, sophisticated event routing for various object lifecycles (create, update, delete), and ensuring idempotent processing using caching mechanisms like Redis. Use this when external microservices must react reliably and immediately to changes within the Foundry Ontology or data assets.

Perform pathway and gene-set enrichment analysis on gene lists or ranked data using tools like gseapy, Enrichr, and g:Profiler. Supports ORA, GSEA, ssGSEA, and functional profiling across GO, KEGG, Reactome, and MSigDB databases. Ideal for interpreting differential expression results, CRISPR screen hits, and cluster markers to identify over-represented biological pathways.

This skill guides authors on how to proactively strengthen their academic manuscripts before submission, especially for highly demanding journals. It involves identifying the most likely expert reviewers, predicting their specific methodological, theoretical, or empirical objections, and strategically integrating countermeasures, robustness checks, and alternative explanations directly into the main text. It transforms the submission process from a defensive reaction to a proactive, structured argument.

This skill computes disproportionality metrics (PRR, ROR, EBGM, IC) using FAERS/OpenFDA drug-event data. It analyzes spontaneous reports to statistically screen for potential drug-reaction associations (Signal of Disproportionate Reporting, SDR). By constructing a 2x2 contingency table, it helps pharmacovigilance professionals identify over-reported adverse events, providing a statistical hypothesis for drug safety assessment.

This skill structures free-text adverse event narratives into the mandatory ICH E2B(R3) format. It populates critical fields required for regulatory submissions (like FAERS/EudraVigilance), including suspect drugs, reactions (mapped via MedDRA), seriousness criteria, and reaction outcomes. Use it when generating Individual Case Safety Reports (ICSRs) from clinical narratives.