Skill UI

Pysam offers Python bindings to htslib for reading and writing SAM/BAM/CRAM alignments, VCF/BCF variants, and FASTA/FASTQ sequences, enabling coverage stats, pileup analysis, variant queries, and seamless integration into NGS pipelines.

Query the JASPAR REST API and Python helpers to retrieve TF binding profiles, convert PFMs to PWMs, and scan DNA sequences for high-confidence motifs, enabling regulatory variant interpretation, ChIP/ATAC analysis, and TF network construction.

This skill provides a comprehensive guide to using the Malpedia API for advanced malware intelligence analysis. Users can track malware family relationships, analyze variant evolution, extract associated YARA rules for detection, and map connections to specific threat actors. It is essential for security researchers and SOC analysts building robust threat models.