Skill UI

This skill provides a systematic framework for evaluating the rigor of scientific claims, research methodology, and evidence quality. It guides users through assessing experimental design validity, identifying various types of biases (e.g., selection, cognitive), and applying established grading frameworks like GRADE or Cochrane Risk of Bias. Ideal for systematic reviews, peer review, and critical analysis of scientific literature.

scikit-bio is a comprehensive Python library designed for advanced bioinformatics and biological data analysis. It provides robust capabilities for sequence manipulation (DNA, RNA, Protein), performing complex sequence alignments (pairwise and multiple), constructing and analyzing phylogenetic trees, and calculating diverse ecological metrics. It is essential for microbiome analysis, evolutionary studies, and general biological data processing, supporting standard formats like FASTA, Newick, and BIOM.

Statsmodels is a robust Python library providing comprehensive tools for advanced statistical analysis. It supports a wide range of models, including Ordinary Least Squares (OLS), Generalized Linear Models (GLM like Poisson and Logistic), Weighted Least Squares (WLS), and complex time series forecasting (ARIMA). Use this skill for rigorous econometrics, detailed diagnostic testing, and generating publication-ready statistical inference.

A comprehensive tutor designed to build robust statistical thinking. It guides users through the entire data analysis lifecycle, from exploratory data visualization and descriptive statistics to complex hypothesis testing and regression modeling. The focus is on understanding the 'why' and 'how' of statistical logic using real datasets and practical problems, rather than just memorizing formulas. It is tool-agnostic, supporting concepts learned in Python, R, SPSS, or Stata.

Utilize the idc-index Python package to access and query massive public datasets from the NCI Imaging Data Commons (IDC). This skill allows users to search, download, and visualize large-scale radiology (CT, MR, PET) and pathology (slide) images. It is essential for AI model training, medical research, and complex medical data analysis.

A comprehensive, structured framework for conducting sophisticated Open Source Intelligence (OSINT) and cryptocurrency forensic investigations. This guide covers operational security (OpSec), target profiling, advanced transaction tracing across multiple blockchain layers (L1/L2), wallet analysis, and identifying linked digital assets. Use this methodology to guide systematic, multi-dimensional intelligence collection campaigns.

Provides a structured workflow for systematically accessing and analyzing official intellectual property data from the USPTO. This skill covers patent search (PatentSearch API), trademark status checks (TSDR), ownership transfer tracking, and building reproducible IP landscape logs. It is designed for data collection and record verification, emphasizing the use of official APIs and rigorous logging practices. (Warning: Not for legal advice.)

A comprehensive tool for performing pathway and gene-set enrichment analysis (GSEA, ORA, ssGSEA, GSVA). Used in computational biology to determine which biological pathways or gene sets are significantly over-represented in a given list of genes or ranked gene data. Supports multiple databases (GO, KEGG, Reactome, MSigDB) and provides tools for result interpretation, visualization, and publication-ready reporting.

This skill generates detailed, structured research protocols for various academic, clinical, or market research studies. It ensures all critical components—such as objectives, study design, participant criteria, methodology, data management, statistical analysis plan, and ethical considerations—are comprehensively documented, providing a robust framework for any scientific investigation.