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This guide provides expert principles for designing and auditing system-level experiments in computer architecture (e.g., for ASPLOS-level conferences). It details the proper usage of various instruments—from real silicon and FPGAs to cycle-level simulators and analytical models—ensuring that every claim is matched to a valid, stated error model. It emphasizes workload selection, establishing strong baselines, performing rigorous ablation studies, and honestly reporting measurement noise and limitations to maintain scientific credibility.