Skill UI

Access the European Nucleotide Archive via REST/FTP to fetch DNA/RNA sequences, raw reads, assemblies, annotations, and taxonomy for research or bioinformatics pipelines.

Query Ensembl’s RESTful API to access gene annotations, sequences, variants, orthologs, and assembly mappings across 250+ species, enabling integration into genomic research pipelines.

Combines ESM3 and ESM C protein language models to generate sequences, predict structures, condition functions, and extract embeddings via local or Forge API inference for protein design and engineering workflows.

gget is a CLI/Python client that unifies querying over 20+ bioinformatics databases, letting researchers fetch gene info, sequences, BLAST results, structures, and enrichment data interactively or within scripts.

Pysam offers Python bindings to htslib for reading and writing SAM/BAM/CRAM alignments, VCF/BCF variants, and FASTA/FASTQ sequences, enabling coverage stats, pileup analysis, variant queries, and seamless integration into NGS pipelines.

scikit-bio provides a Python-native biological data toolkit for reading/writing FASTA/Newick files, manipulating sequences, building alignments and phylogenies, and calculating diversity metrics for microbiome and ecology workflows.

Direct REST API access to UniProt for searching proteins, fetching FASTA sequences, mapping identifiers, selecting annotations, and streaming large datasets within Python workflows.

Analyzes protein sequences to locate canonical N-glycosylation sequons, predict O-glycosylation hotspots, and mutate or design glycosylation sites for therapeutic proteins, vaccines, and biosimilar comparisons using curated glycoengineering resources.

Query the JASPAR REST API and Python helpers to retrieve TF binding profiles, convert PFMs to PWMs, and scan DNA sequences for high-confidence motifs, enabling regulatory variant interpretation, ChIP/ATAC analysis, and TF network construction.

A comprehensive toolkit for reconstructing and analyzing the evolutionary history of biological sequences (genes, proteins, genomes). The standard workflow includes multiple sequence alignment using MAFFT, robust maximum likelihood tree inference with IQ-TREE 2 and FastTree, and advanced visualization/manipulation using ETE3. This skill is essential for studies in viral phylodynamics, microbial genomics, protein family evolution, and molecular clock dating.

This skill guides the creation, refinement, and iteration of highly personalized B2B cold outreach email sequences. It ensures that all communications sound genuinely human and thoughtful, avoiding the tone of a 'sales machine.' Users can utilize it to write initial first-touch emails, build multi-stage follow-up campaigns, or analyze performance data (open/reply rates) to improve underperforming sequences. Ideal for sales development representatives (SDRs) and marketing professionals focusing on unsolicited prospect engagement.

This expert skill guides you through the entire process of creating, optimizing, and structuring automated email flows, including welcome, nurture, and re-engagement sequences. It ensures every email has a clear purpose, defined metrics, and a structured CTA, allowing you to move users efficiently through the entire customer lifecycle and maximize conversion rates.