Skill UI

Arboreto infers gene regulatory networks from bulk or single-cell RNA-seq data using scalable GRNBoost2 and GENIE3 algorithms, letting researchers filter transcription-factor targets, run distributed Dask jobs, and export ranked links for downstream analysis.

Dask is a Python library that scales pandas/NumPy workflows beyond RAM by parallelizing DataFrames, Arrays, Bags, and custom tasks across cores or clusters for ETL, log analysis, and distributed ML.

Zarr is a Python toolkit for chunked N-D array storage with compression, sharding, and native integrations with NumPy/Dask/Xarray, ideal for parallel I/O and scalable cloud pipelines.

Arboreto is a powerful Python library designed to infer Gene Regulatory Networks (GRNs) from various gene expression datasets, including bulk and single-cell RNA-seq. It employs scalable algorithms like GRNBoost2 and GENIE3 to identify critical transcription factor-target gene relationships. Featuring support for Dask distributed computing, Arboreto is optimized for large-scale, high-throughput transcriptomic analysis.

Dask is a powerful Python library designed for parallel and distributed computing. It allows users to scale existing pandas and NumPy workflows beyond the limits of available RAM, processing massive datasets up to the terabyte scale. It provides specialized APIs (DataFrames, Arrays, Bags) for handling structured, scientific, and unstructured data efficiently across single machines or multi-node clusters.

This skill proactively detects and reports comprehensive system resources, including CPU cores, GPU types (NVIDIA, AMD, Apple Silicon), available memory, and disk space. It generates a detailed JSON report with strategic, context-aware recommendations for optimizing scientific computing workflows, such as recommending parallel processing libraries (Dask, joblib), out-of-core methods (Zarr), or appropriate GPU acceleration backends (Metal, ROCm). Use this before any large-scale data analysis, model training, or computationally intensive simulation to make informed architectural decisions.

Zarr is a robust Python library designed for storing massive N-dimensional arrays. It supports efficient chunking, compression, and parallel I/O, making it ideal for large-scale scientific computing pipelines. Seamlessly integrates with NumPy, Dask, and Xarray, and supports cloud storage backends like S3 and GCS via fsspec, ensuring high performance in cloud-native environments.