Skill UI

Provide REST API access to ClinPGx, the successor to PharmGKB, for querying gene-drug interactions, CPIC/DPWG/FDA guidelines, allele functions, and evidence that supports precision dosing and pharmacogenomics-driven clinical decisions.

Integrate with the DNAnexus cloud genomics platform to build apps/applets, manage FASTQ/BAM/VCF data, run workflows, and script automations via dxpy for biomedical pipelines.

A toolkit for phylogenetic tree manipulation, event detection, NCBI taxonomy integration, and publication-quality visualization, streamlining phylogenomics workflows and gene family analysis.

TileDB-VCF lets you ingest, store, query, and export large genomic VCF/BCF datasets using TileDB’s sparse arrays, supporting incremental sample growth, parallel regions queries, and cloud-local interoperability for population genomics workflows.

Access multi-dimensional cancer genomics data via cBioPortal REST API for mutation, copy-number, expression, and survival insights across TCGA/GENIE studies, enabling target validation and clinical association analyses programmatically with Python clients.

A comprehensive toolkit for reconstructing and analyzing the evolutionary history of biological sequences (genes, proteins, genomes). The standard workflow includes multiple sequence alignment using MAFFT, robust maximum likelihood tree inference with IQ-TREE 2 and FastTree, and advanced visualization/manipulation using ETE3. This skill is essential for studies in viral phylodynamics, microbial genomics, protein family evolution, and molecular clock dating.

polars-bio accelerates genomic interval math and bioinformatics I/O by combining Polars, Arrow, and DataFusion to handle BED/VCF/BAM/GFF/FASTA streams, SQL queries, and cloud storage with overlap, coverage, and nearest APIs plus streaming fallbacks.

Anndata is a Python package for handling annotated data matrices, storing experimental measurements alongside observation and variable metadata. It supports single-cell genomics analysis, managing h5ad and Zarr files efficiently. Users can read, write, concatenate, and subset data with sparse matrix support. It integrates with the scverse ecosystem including Scanpy and scvi-tools. Ideal for biological data workflows requiring efficient storage and manipulation.

Build and operate reproducible genomics workloads on DNAnexus using dx CLI, dxpy SDK, apps/applets, native workflows, dxCompiler, and Nextflow. Supports data transfers, execution monitoring, workflow import, and project automation with secure authentication and compliance controls for regulated data handling.

This skill enables the construction and analysis of phylogenetic trees using tools like MAFFT for alignment, IQ-TREE 2 for maximum likelihood inference, and FastTree for large datasets. It supports evolutionary analysis, microbial genomics, viral phylodynamics, and molecular clock studies. Visualization is handled via ETE3 or FigTree. Ideal for inferring evolutionary relationships, detecting horizontal gene transfer, and reconstructing ancestral sequences in biological research.

scvi-tools is a comprehensive Python framework for probabilistic deep generative models in single-cell genomics. Built on PyTorch and PyTorch Lightning, it enables batch correction, transfer learning, differential expression analysis with uncertainty, and multi-modal data integration. Best for advanced modeling of single-cell RNA-seq, ATAC-seq, CITE-seq, spatial transcriptomics, and specialized modalities like methylation and cytometry.

Store and query genomic variant data with TileDB sparse arrays. Ingest VCF/BCF files, add samples incrementally, run parallel region queries, and export subsets for population genomics workflows.