Skill UI

Arboreto is a powerful Python library designed for inferring Gene Regulatory Networks (GRNs) from various gene expression datasets, including bulk and single-cell RNA-seq data. It leverages advanced machine learning algorithms like GRNBoost2 and GENIE3. The library supports scalable, distributed computation using Dask, making it ideal for analyzing large-scale, complex transcriptomics datasets to identify critical transcription factor-target gene relationships.

LaminDB is an open-source, lineage-native lakehouse designed for managing complex biological datasets and computational workflows. It makes diverse scientific data (like scRNA-seq, AnnData) queryable, traceable, and compliant with FAIR principles. Core capabilities include robust data lineage tracking, schema validation, ontology-backed annotation (Bionty), and unified querying across multiple cloud/local storage systems. It is essential for bioinformatics research and building reproducible data infrastructure.

This comprehensive guide provides authors with deep insight into Nature Immunology's high standards. It covers everything from field-shifting scientific significance and required mechanistic evidence (e.g., in vivo models, scRNA-seq) to specific house styles, abstract structure, and optimal venue selection. Use this skill for pre-submission vetting and improving the conceptual framing of your immunology research.